Abstract
3-Benzimidazol-2-yl-1H-indazole analogs were developed as inhibitors of receptor tyrosine kinases (RTK). The synthesis and SAR of this series is reported.
MeSH terms
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Animals
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / chemistry
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Benzimidazoles / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Drug Design
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Indazoles / chemical synthesis*
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Indazoles / chemistry
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Indazoles / pharmacology*
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Mice
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Mice, Nude
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Models, Molecular
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Molecular Structure
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Receptor Protein-Tyrosine Kinases / antagonists & inhibitors*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Benzimidazoles
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Indazoles
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Receptor Protein-Tyrosine Kinases